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Berberine
Berberine Hydrochloride Extract60 capsules · 30 servings
- 800 mg berberine hydrochloride extract per serving
- About 73 mg of berberine itself, from an 8% and a 97% extract
- Vegetable capsule
Coming soon
This product is not on sale yet.
One container is 30 servings: about 30 days at the label amount.
Berberine changes how the body handles many prescription medicines. Ask a doctor first if you take any.
- The manufacturer's lab report covers strength, heavy metals and microbes. What that means
The whole label
What’s in it
| Serving size 2 capsules | ||
| Servings per container 30 | ||
| Amount per serving | Amount | % Daily Value** |
|---|---|---|
| Granular Berberine Hydrochloride Extract 8%(bark/root) | 790 mg | ** |
| Granular Berberine Hydrochloride Extract 97%(bark) | 10 mg | ** |
| **Daily Value (DV) not established. | ||
- Other Ingredients:
- Cellulose (vegetable capsule), MCC (microcrystalline cellulose), L-Leucine, Olive Oil.
- Form
- Capsule
- Contents
- 60 capsules
- Servings
- 30 (2 capsules each)
- Lasts
- About 30 days at the label amount
- Manufactured in
- USA, according to the manufacturer. Where the ingredients come from is not stated.
- Manufacturer states
- gluten-free, vegetarian, vegan friendly
Directions
How to take it
Take two capsules a day.
Directions on the label
As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-236ml) of water or as directed by healthcare professional.
Label warnings
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
Graded honestly
What the evidence says
Two capsules give 790 mg of a berberine extract standardized to 8% and 10 mg of an extract standardized to 97%. That works out to about 73 mg of berberine hydrochloride a day. The human trials of berberine used 500 to 1,500 mg a day, most often around 900 to 1,500 mg, and nearly all of them enrolled patients under medical care. This product supplies about one twelfth of the lower end of the common range. We make no benefit claim for this product.
How it works
Berberine is a bitter yellow compound found in the bark and roots of several plants, including goldenseal and Chinese goldthread (Coptis). NIH's National Center for Complementary and Integrative Health notes that very little berberine taken by mouth may be absorbed. Researchers are still working out how it acts in the body. What is well documented in people is that at 900 mg a day it slows three liver enzymes that break down many common medicines, which is why it can raise or lower the levels of drugs taken with it.
The dose in this product
No benefit is claimed, because the label dose is far below the studied dose. The arithmetic: 790 mg of an 8% extract is 790 × 0.08 = 63.2 mg of berberine hydrochloride.
How that compares with the studiesHide the comparison
10 mg of a 97% extract is 10 × 0.97 = 9.7 mg. Together that is about 73 mg a day, or about 36 mg per capsule. The supplier's lab report on its own sample lot measured somewhat more berberine than this arithmetic gives.
It is still about a tenth of the studied amount. In a pooled analysis of 14 trials, berberine was generally given at 0.5 to 1.5 g a day, split into two or three doses, for 8 to 24 weeks. A larger pooled analysis of 49 trials found the best results for blood fats and body weight at about 1 g a day.
Many of the trials used 900 mg (300 mg three times a day) or 1,500 mg (500 mg three times a day). At 73 mg, this product gives about 15% of the lowest common trial dose (500 mg) and about 5% to 8% of the 900 to 1,500 mg range. Reaching 900 mg would take about 25 capsules a day, and the bottle holds 60.
Nearly all of the trials enrolled patients under medical care, most of them in China, and most trials were rated at high risk of bias. Changes in blood sugar or cholesterol in such patients are not claims a supplement can make. We found no trial of berberine at about 73 mg a day for any outcome.
We make no health claim for this product.
The studies we found did not test the amount or form it provides, so nothing passed our review. The notes beside this box say what was studied.
Strong evidence: many human trials agree, at the amount in this product. Moderate evidence: human trials mostly agree, but they are small, short or mixed. Early evidence: a few small human studies or lab work. Promising, not proven.
Safety
Who it is for, and who should ask first
Do not use if
- You are pregnant or breastfeeding. NIH's National Center for Complementary and Integrative Health says pregnant or breastfeeding women should not use goldenseal, whose main compound is berberine, because berberine can be harmful to newborns.
- You would give it to a baby or child. Berberine can push bilirubin off the blood protein that carries it, which in newborns raises the risk of kernicterus, a form of brain injury. The label says it is for adults.
Good fit if
- People who want a small amount of berberine and understand it is far below the amounts used in studies
- People who are not looking for a blood sugar, cholesterol or body weight result
- Not for anyone taking prescription medicines unless their doctor or pharmacist has said it is fine
Ask your doctor first if
- You take any prescription medicine. Berberine changes how the body handles many drugs
- You have diabetes or take medicine that lowers blood sugar, including insulin and metformin
- You take cyclosporine or another medicine where small changes in blood level matter, such as after an organ transplant
- You have liver disease, or a history of jaundice or G6PD deficiency
- You are under 18 or have a known medical condition (label caution)
Interactions
- Medicines broken down by the liver enzymes CYP3A4, CYP2D6 and CYP2C9. In healthy men, berberine at 900 mg a day for two weeks raised blood levels of midazolam (a sedative) by about 40%, and slowed the breakdown of dextromethorphan (a cough medicine) and losartan (a blood pressure medicine). Many other drugs use these enzymes, including some blood thinners such as warfarin (expected from how the two work, not tested). Whether 73 mg a day has a measurable effect is unknown. Ask your pharmacist.
- Cyclosporine (an anti-rejection medicine): in kidney transplant patients, 600 mg of berberine a day raised cyclosporine blood levels. In a small study it raised total exposure by about 35%. Do not combine without your transplant team.
- Metformin: in 16 healthy adults, goldenseal extract (standardized to berberine) lowered metformin levels in the blood by about 23%, which may make blood sugar harder to control. That study used goldenseal, not purified berberine.
- Insulin and other diabetes medicines: in trials, berberine at 0.5 to 1.5 g a day lowered blood sugar in people with diabetes, and adding it to diabetes medicines lowered it further. Taken together they could push blood sugar too low. Ask your doctor first.
Possible side effects
- Upset stomach, constipation, diarrhea, gas or cramping. In one trial at 1.5 g a day, about a third of patients had short-lived digestive effects
- Pooled analyses report no serious side effects in trials of up to about two years, but most trials were small and many did not report side effects well
Upper limit
No tolerable upper intake level has been set for berberine. Trials most often used 0.5 to 1.5 g a day for 8 to 24 weeks, and a pooled analysis of 49 trials included doses up to several grams a day for up to two years (Zamani 2022). There are no safety studies of this capsule formula.
The label says not to exceed two capsules a day.
Combining with our other products
No other product in this line contains berberine, so there is no double dosing. Berberine does not change how the line's vitamins and minerals are absorbed as far as we know. The concern is prescription medicines, not other products here.
If you take any medicine, show this label to your pharmacist.
Lab reports
What the lab report covers
We hold the manufacturer’s lab report for a production lot of this product. It reports on the manufacturer’s own lot, not on the container you receive. This is what it covers and what it leaves out.
Berberine content is measured.
- Strength of the main ingredient
- Measured
- Identity test
- Not reported
- Heavy metals
- Measured
- Microbes
- Tested
- Lab named on the report
- No
- Latest report
- February 2026
Answers
Questions people ask
How much berberine is in a serving?
About 73 mg of berberine hydrochloride in two capsules. The 790 mg extract is 8% berberine, which is about 63 mg, and the 10 mg extract is 97% berberine, which is about 10 mg. Most studies used 900 to 1,500 mg a day.
Is berberine "nature's Ozempic"?
No. Ozempic is a prescription medicine (semaglutide) that copies a gut hormone and is given by injection. Berberine is a plant compound that works differently and was studied at doses more than ten times what this product gives. In a pooled analysis of 49 trials, people taking berberine weighed on average less than 1 kg less than people in the comparison groups, a very small difference.
Why do you make no health claim for this product?
Because the amount is too small. Our rule is that we only claim what studies found at the dose a product provides. This product gives about 73 mg a day, and the studies used 500 mg or more, nearly all in patients under medical care. We found no study at this dose.
What do the 8% and 97% on the label mean?
They are how much of each extract is berberine hydrochloride. Most of the 790 mg ingredient is plant material, and only 8% of it is berberine. The label does not name the plant the bark and root came from.
Can I take more capsules to reach the studied dose?
No. The label says not to exceed two capsules a day. Reaching 900 mg would take about 25 capsules. At studied doses berberine slows the breakdown of many medicines and often upsets the stomach. If you are thinking about a higher dose, talk to your doctor or pharmacist.
Can I take it with metformin or other diabetes medicines?
Ask your doctor first. Berberine lowered blood sugar in trials of people with diabetes, and adding it to diabetes medicines lowered blood sugar further, so the two together could push it too low. Goldenseal, which contains berberine, lowered metformin levels in healthy adults by about 23%.
Is it safe during pregnancy or breastfeeding?
Do not use it. NIH says pregnant or breastfeeding women should not use goldenseal because its berberine can be harmful to newborns. Berberine can push bilirubin off its carrier protein in the blood, which raises the risk of jaundice causing brain injury (kernicterus) in newborns.
Does it interact with my medicines?
It may. At 900 mg a day, berberine slowed three liver enzymes (CYP3A4, CYP2D6 and CYP2C9) that break down many common drugs, and it raised blood levels of cyclosporine in transplant patients. The effect of 73 mg a day has not been tested. Show the label to your pharmacist before you start.
Read the studies
Sources
- 1.National Center for Complementary and Integrative Health. Goldenseal. U.S. National Institutes of Health. Open source (opens in a new tab)Berberine is the main compound in goldenseal and very little of it may be absorbed when taken by mouth. Goldenseal should not be used during pregnancy or breastfeeding or given to infants, because berberine can be harmful to newborns, and it lowered metformin levels in an NIH funded study.
- 2.Li Z, Wang Y, Xu Q, et al. Berberine and health outcomes: An umbrella review. Phytother Res. 2023;37(5):2051-2066. Open source (opens in a new tab)Across 11 meta-analyses of randomized trials published from 2013 to 2022, berberine changed blood sugar, blood fat and body measures compared with controls, mostly in patient groups. The authors rated the methods of the meta-analyses as needing improvement and listed constipation and diarrhea as common side effects.
- 3.Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. Open source (opens in a new tab)Pooled 14 randomized trials with 1,068 patients under medical care. Berberine was generally given at 0.5 to 1.5 g a day in two or three doses for 8 to 24 weeks. The trials were of generally low quality and reported no serious side effects.
- 4.Zamani M, Zarei M, Nikbaf-Shandiz M, et al. The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis. Front Nutr. 2022;9:1013055. Open source (opens in a new tab)Pooled 49 randomized trials, 38 of them rated at high risk of bias. Berberine lowered blood fats and fasting blood sugar and reduced body weight by an average of 0.84 kg compared with controls, with the best effect on blood fats and weight at about 1 g a day.
- 5.Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol. 2012;68(2):213-7. Open source (opens in a new tab)In healthy men, berberine at 300 mg three times a day for two weeks slowed the liver enzymes CYP2D6, CYP2C9 and CYP3A4. Midazolam exposure rose by about 40% and the dextromethorphan ratio rose ninefold.
- 6.Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol. 2005;61(8):567-72. Open source (opens in a new tab)In kidney transplant recipients, 0.2 g of berberine three times a day left cyclosporine trough levels about 29% higher than without berberine after three months. In six patients it raised cyclosporine exposure by about 35%.
- 7.Nguyen JT, Tian DD, Tanna RS, et al. Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail. Clin Pharmacol Ther. 2021;109(5):1342-1352. Open source (opens in a new tab)In 16 healthy adults, a goldenseal extract standardized to berberine lowered metformin exposure by about 23% and raised midazolam exposure by about 43%. The authors said the metformin change may have unfavorable effects on blood sugar control.
- 8.Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate. 1993;63(4):201-8. Open source (opens in a new tab)In lab tests berberine pushed bilirubin off albumin, its carrier protein, about ten times more strongly than a known displacing drug, and it raised unbound bilirubin in rats. The author advised that berberine be avoided in newborns with raised bilirubin and in pregnant women.
Reviewed 2026-10-13. This page is information, not medical advice.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.