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Sleep and Stress
Ashwagandha Complex
Ashwagandha Extract with Vitamins B6, B12 and D360 capsules · 30 servings
- 600 mg ashwagandha extract per serving
- The label names KSM-66, standardized to 5% withanolides
- With vitamins D3, B6 and B12
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This product is not on sale yet.
One container is 30 servings: about 30 days at the label amount.
Do not use if you are pregnant or breastfeeding.
- The manufacturer's lab report covers heavy metals and microbes, and part of the strength. What that means
The whole label
What’s in it
| Serving size 2 capsules | ||
| Servings per container 30 | ||
| Amount per serving | Amount | % Daily Value |
|---|---|---|
| Vitamin D3(as Cholecalciferol) | 20 mcg | 100% |
| Vitamin B6(as Pyridoxine Hydrochloride) | 2.5 mg | 147% |
| Vitamin B12(as Methylcobalamin 1%) | 25 mcg | 1042% |
| KSM-66® Ashwagandha Extract(standardized to 5% Withanolides) | 600 mg | ** |
| L-Arginine | 300 mg | ** |
| Maca Root Powder(Lepidium meyenii) (root) | 150 mg | ** |
| Panax Ginseng Powder(root) | 100 mg | ** |
| Shatavari Powder(Asparagus racemosus) (root) | 50 mg | ** |
| **Daily Value (DV) not established. | ||
- Other Ingredients:
- HPMC (vegetable capsule)
- Form
- Capsule
- Contents
- 60 capsules
- Servings
- 30 (2 capsules each)
- Lasts
- About 30 days at the label amount
- Manufactured in
- USA, according to the manufacturer. Where the ingredients come from is not stated.
- Manufacturer states
- gluten-free, vegetarian
About the ingredients: Ashwagandha, Panax ginseng, L-arginine, Maca, Shatavari, Vitamin B12, Vitamin B6, Vitamin D
Directions
How to take it
Take two capsules a day with water.
Directions on the label
As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-237ml) of water or as directed by healthcare professional.
Label warnings
Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.
Graded honestly
What the evidence says
Two capsules give 600 mg of ashwagandha extract, which the label names as KSM-66 (a root extract), plus vitamin D, B6 and B12. That is the extract and daily amount used in most of the trials described here. Several small trials found lower stress scores and lower cortisol after about 8 weeks, with thinner evidence for sleep quality and for strength gains alongside weight training. The arginine, maca, ginseng and shatavari are far below studied amounts, and ashwagandha has real safety questions (rare liver injury, thyroid and hormone effects, pregnancy) that are set out below.
How it works
Ashwagandha is a shrub whose root has long been used in Ayurvedic practice as an adaptogen, a loose term for something meant to help the body cope with stress. Compounds called withanolides are thought to be responsible for many of its effects, though other parts of the root may matter too. In trials, people taking the extract had lower blood levels of the stress hormone cortisol; how the plant does this is not established. Vitamin D helps the body absorb calcium and is needed by muscles and the immune system. Vitamins B6 and B12 help enzymes release energy from food and keep nerves and red blood cells working normally.
The dose in this product
Ashwagandha: the trials behind the claims used KSM-66 root extract at 600 mg a day for 8 to 12 weeks, usually as one 300 mg capsule twice a day. Two capsules of this product supply the same 600 mg, standardized to 5% withanolides (about 30 mg), so the dose and form match.
How that compares with the studiesHide the comparison
NIH notes that benefits looked greater at 500 to 600 mg a day than at lower doses, and the one trial that tested both found 600 mg worked better than 250 mg. No trial has run longer than about three months. The KSM-66 trials at 600 mg a day, with size and funding: stress, 64 adults for 60 days (extract provided by the maker, Ixoreal Biomed; no other funding declared) and 60 adults in three groups for 8 weeks (extract gifted by the maker); sleep, 60 adults with diagnosed sleep problems for 10 weeks, 80 adults (half with diagnosed sleep problems) for 8 weeks and 50 adults aged 65 to 80 for 12 weeks (extract supplied by the maker in each); strength, 57 men for 8 weeks and 80 men and women for 8 weeks (extract supplied by the maker; the second declared no grants).
All were run in India. Vitamins: 20 mcg of vitamin D, 2.5 mg of B6 and 25 mcg of B12 meet or exceed the Daily Value. No claims are made for the other four ingredients because the amounts are far below those studied: L-arginine 300 mg (a normal diet supplies 4 to 5 g a day, and NIH found 2 to 20 g a day did little for performance); maca 150 mg (trials used 1,500 to 3,500 mg a day); Panax ginseng root powder 100 mg (trials used 350 to 3,000 mg a day, and doses under 1,000 mg showed no significant effect on fatigue); shatavari 50 mg (one small trial used 1,000 mg a day).
- Moderate evidence
Helps the body handle occasional stress, with lower cortisol levels measured in trials
Two placebo-controlled trials of KSM-66 at 600 mg a day (64 adults for 60 days; 60 adults in three groups for 8 weeks) found lower stress questionnaire scores and lower blood cortisol than placebo; in the larger trial cortisol fell 27.9% against 7.9% on placebo. NIH's summary of seven trials (491 adults, all in India) points the same way, but the trials were small and short and the maker supplied the extract. [3][4][1]
- Early evidence
May support sleep quality
A meta-analysis of five small trials (400 adults, all in India; four used KSM-66) found a small improvement in sleep over placebo, larger at 600 mg a day and after 8 weeks or more. The effect was strongest in people with diagnosed sleep problems; for healthy adults the evidence comes from three small KSM-66 trials. [5][1]
- Early evidence
May support strength gains when combined with resistance training
Two 8-week trials of KSM-66 at 600 mg a day alongside a resistance training programme (57 young men; 80 men and women) reported larger strength gains than placebo; in the first, bench press rose 46 kg against 26 kg. Both were run in India with extract supplied by the maker, and the first enrolled men with little training experience. [6][7]
- Moderate evidence
Provides vitamin D for normal muscle and immune function, and vitamins B6 and B12 for normal energy metabolism and nervous system function
These are established nutrient functions, authorised as health claims in the EU for foods that supply these vitamins; two capsules provide 100% of the US Daily Value for vitamin D, 147% for B6 and 1,042% for B12. If your diet already covers them, extra is not known to add anything: NIH notes that B12 does not improve energy or performance in people who are not deficient. [8]
Strong evidence: many human trials agree, at the amount in this product. Moderate evidence: human trials mostly agree, but they are small, short or mixed. Early evidence: a few small human studies or lab work. Promising, not proven.
Safety
Who it is for, and who should ask first
Do not use if
- You are pregnant, trying to conceive or breastfeeding. NIH says ashwagandha should be avoided in pregnancy and not used while breastfeeding.
Good fit if
- Healthy adults under everyday stress who want the extract and dose used in the trials
- Adults starting a resistance training programme
- People who can commit to about 8 weeks of daily use, the length of most trials
Ask your doctor first if
- You have liver disease, or have ever had jaundice or abnormal liver tests
- You have a thyroid condition or take thyroid hormone
- You have an autoimmune condition or take medicines that suppress the immune system
- You take sedatives, sleep medicines or anti-seizure medicines
- You take medicines for diabetes or blood pressure
- You have hormone-sensitive prostate cancer (ashwagandha may raise testosterone)
- You take a blood thinner such as warfarin
- You are about to have surgery
- You are under 18
- You already take vitamin D from another supplement
Interactions
- Thyroid hormone medicines: ashwagandha raised thyroid hormone levels in a trial and has been linked to cases of overactive thyroid.
- Sedatives and sleep medicines: ashwagandha can cause drowsiness and may add to their effect.
- Diabetes medicines: ashwagandha and ginseng may lower blood sugar further.
- Blood pressure medicines: ashwagandha may add to their effect.
- Immunosuppressants: ashwagandha may affect the immune system and work against these drugs.
- Anti-seizure medicines: listed by NIH as a possible interaction.
- Warfarin and other blood thinners: Asian ginseng may interfere with blood clotting.
- Other vitamin D supplements, and thiazide water pills: extra vitamin D adds up, and the combination with thiazides can raise blood calcium.
Possible side effects
- Stomach upset, nausea or loose stools
- Drowsiness
- Headache or dizziness (less common)
- Skin rash (less common)
- Rare but serious: liver injury, usually starting 2 to 12 weeks after beginning ashwagandha, with yellow skin or eyes, dark urine or itching. Stop taking it and see a doctor if these appear.
Upper limit
No upper limit has been set for ashwagandha, and Germany's risk assessment institute (BfR) says the data do not allow a safe intake level to be derived. Trials used 600 mg a day of root extract for up to about three months; safety beyond that is unknown. Vitamin D: the US upper limit for adults is 100 mcg (4,000 IU) a day from all sources (NIH Office of Dietary Supplements); this product has 20 mcg.
Vitamin B6: the US upper limit is 100 mg a day, and the European Food Safety Authority set a lower limit of 12 mg a day in 2023; this product has 2.5 mg. Vitamin B12 has no upper limit.
Combining with our other products
Vitamin D adds up quickly across this line. Ashwagandha Complex has 20 mcg, Vitamin D3 has 50 mcg, Immune Support has 40 mcg, Men's Multi has 10 mcg and chocolate Plant Protein has 2 mcg. Ashwagandha Complex with Vitamin D3 is 70 mcg.
Add Immune Support and the total is 110 mcg, above the adult upper limit of 100 mcg; all five together reach 122 mcg. Choose one main source of vitamin D. Vitamin B6 also overlaps: 2.5 mg here, 7.5 mg in Men's Multi, 2.5 mg in BCAA 2:1:1 and 1.7 mg in Immune Support total 14.2 mg, far under the US limit of 100 mg but over the 12 mg limit set in Europe.
Sleep: both products can cause drowsiness, so do not start them together, and do not drive after taking both. Mushroom Complex and Immune Support contain immune-active ingredients; if a doctor has told you to avoid ashwagandha because of an autoimmune condition or immune-suppressing medicine, ask about those too.
Lab reports
What the lab report covers
We hold the manufacturer’s lab report for a production lot of this product. It reports on the manufacturer’s own lot, not on the container you receive. This is what it covers and what it leaves out.
The vitamins and arginine are measured. The ashwagandha extract is not.
- Strength of the main ingredient
- Partly measured
- Identity test
- Reported
- Heavy metals
- Measured
- Microbes
- Tested
- Lab named on the report
- No
- Latest report
- November 2025
Answers
Questions people ask
How long before I notice anything?
The trials measured results after about 8 weeks of daily use (60 days in the largest stress trial). Do not expect an effect within days. No trial has gone past about three months, so there is no evidence about what longer use does.
Is it safe to take long term?
Nobody knows. NIH says ashwagandha appears well tolerated for up to about three months and that long-term safety is not known. If you want to use it for longer, talk to a doctor.
Can ashwagandha harm the liver?
Rarely, yes. NIH's LiverTox database rates ashwagandha a likely cause of liver injury in rare cases, usually 2 to 12 weeks after starting. Most people recovered within 1 to 4 months of stopping, but a few cases were fatal or needed a transplant, mainly in people who already had liver disease. Do not take it if you have liver disease, and stop and see a doctor if you notice yellow skin or eyes, dark urine or itching.
Does it affect thyroid or other hormones?
It can. In a trial of 50 people with a mildly underactive thyroid, 600 mg a day changed thyroid hormone levels within 8 weeks, and there are case reports of overactive thyroid. It may also raise testosterone in men. Talk to a doctor first if you have a thyroid condition, take thyroid medicine or have a hormone-sensitive condition.
Can I take it while pregnant or breastfeeding?
No. NIH's complementary health center says ashwagandha should be avoided during pregnancy and should not be used while breastfeeding. Several European food safety agencies give the same advice.
Why is ashwagandha restricted in some countries?
Denmark banned it in supplements in 2023 after a Danish risk assessment concluded that no safe dose could be set, citing possible effects on thyroid and sex hormones and on pregnancy. French and German agencies have since advised children, pregnant and breastfeeding women and people with liver or thyroid conditions not to use it, and the Dutch public health institute advises consumers not to use it at all. It remains legal in the US, where NIH says it appears well tolerated for up to about three months.
What do the arginine, maca, ginseng and shatavari add?
At these amounts, probably nothing you would notice. Each is present at a small fraction of what studies used: for example 150 mg of maca against 1,500 mg or more in trials. We make no claims for them.
Should I take it in the morning or at night?
The trials gave one 300 mg capsule twice a day; this product's serving is two capsules, which supplies the same 600 mg either way. It makes some people drowsy, so see how it affects you before driving.
Read the studies
Sources
- 1.National Institutes of Health, Office of Dietary Supplements. Ashwagandha: Is it helpful for stress, anxiety, or sleep? Fact Sheet for Health Professionals. Updated May 2, 2025. Open source (opens in a new tab)Small, short trials suggest ashwagandha extracts may reduce stress and improve sleep, with greater benefit at 500 to 600 mg a day; it appears well tolerated for about three months, long-term safety is unknown, and it may affect the liver and thyroid and is not advised in pregnancy.
- 2.LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Ashwagandha. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. Last update December 3, 2024. Open source (opens in a new tab)Ashwagandha is rated a likely cause (score B) of rare, clinically apparent liver injury, typically 2 to 12 weeks after starting, usually resolving within 1 to 4 months of stopping, with rare fatal cases mainly in people whose liver was already damaged.
- 3.Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. Open source (opens in a new tab)In 64 adults reporting chronic stress, KSM-66 at 300 mg twice a day for 60 days lowered perceived stress scores by 44% (5.5% on placebo) and blood cortisol by 27.9% (7.9% on placebo); the maker provided the extract.
- 4.Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. 2019;11(12):e6466. Open source (opens in a new tab)In 60 stressed but healthy adults split into three groups for 8 weeks, KSM-66 at 600 mg a day lowered stress scores and cortisol more than placebo and more than 250 mg a day, and improved self-rated sleep quality; the maker gifted the extract.
- 5.Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. Open source (opens in a new tab)Five trials with 400 participants, all in India and four using KSM-66, showed a small but significant improvement in sleep, more marked in people with diagnosed sleep problems, at 600 mg a day or more and after at least 8 weeks.
- 6.Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. Open source (opens in a new tab)In 57 young men with little training experience, KSM-66 at 300 mg twice a day during 8 weeks of resistance training gave larger gains in bench press (46.0 kg against 26.4 kg) and leg extension strength than placebo, and a larger rise in testosterone.
- 7.Verma N, Gupta SK, Patil S, Tiwari S, Mishra AK. Effects of ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults performing resistance training: an eight-week, prospective, randomized, double-blind, placebo-controlled study. F1000Res. 2023;12:335 (revised version published April 8, 2024). Open source (opens in a new tab)In 80 active men and women (73 analysed), KSM-66 at 300 mg twice a day during 8 weeks of resistance training improved bench press, leg press and endurance more than placebo; the maker supplied the extract.
- 8.European Commission. Commission Regulation (EU) No 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods. Official Journal of the European Union. 2012;L 136:1-40. Open source (opens in a new tab)The EU authorises statements that vitamin D contributes to normal muscle function, the immune system and calcium absorption, and that vitamins B6 and B12 contribute to normal energy-yielding metabolism, the nervous system and red blood cell formation.
Reviewed 2026-10-01. This page is information, not medical advice.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.