Quick answer
Lemon balm is a lemon-scented herb taken as tea or extract. In small studies, some single doses between 300 and 1,600 mg raised self-rated calm for a few hours, and 400 mg a day of one extract gave better sleep scores in two short trials. Both findings are graded early, and it is generally well tolerated.1,2,3,4,5
Key facts
- The two placebo-controlled sleep trials both used the same branded extract, so their results may not carry over to teas or other products.3,4
- Rosmarinic acid from lemon balm peaks in the blood about an hour after a dose on an empty stomach.6
- Older adults took a lemon balm extract daily for 96 weeks in one trial, with no differences from placebo in vital signs or physical measures.7
- NIH's liver injury database reports no link between lemon balm extracts and liver harm.8
What lemon balm is
Lemon balm is a flowering perennial native to the eastern Mediterranean and western Asia, now grown widely.8
Lemon balm contains rosmarinic acid and other polyphenols, and a lemon-scented essential oil with citronellal, neral and geranial.5
In laboratory work, compounds in one lemon balm extract slowed the breakdown of GABA, a calming messenger in the brain. This is a proposed explanation for its effects, not something measured in people.9
FDA lists lemon balm as generally recognized as safe as a food flavoring.5
NIH's complementary health center publishes fact sheets on many herbs, but not on lemon balm. Most of what is known comes from small trials and from NIH's liver and lactation databases.5,8,10
What the evidence shows
Both claims below are graded early: a handful of small, short trials, two of them with authors tied to the company behind the product tested. The amount studied sits beside each claim.4,11
May increase feelings of calm for a few hours after a single dose*1,2,11,12
Early evidence
Three small crossover trials from one UK group gave healthy young adults single doses and tracked mood for up to 6 hours. Self-rated calmness rose after 300 mg of one extract and after 1,600 mg of dried leaf, and 600 mg lessened the drop in mood caused by a stressful multitasking test in 18 people. Some doses slowed memory tasks or lowered alertness. In a larger 2026 trial of 106 stressed young adults, 300 mg did not change overall calmness, the main outcome, though calm returned faster after demanding tasks.
Amount studied: Single doses of 300 to 1,600 mg, depending on the product
May improve self-rated sleep quality, in short trials of one extract*3,4,9
Early evidence
Two randomized trials tested the same phospholipid-bound extract at 400 mg a day. In 100 adults with poor sleep or moderate stress, three weeks lowered scores on a standard sleep quality questionnaire much more than placebo, but the lemon balm group started with worse sleep. In a crossover trial of 30 adults, 400 mg taken 30 minutes before bed for two weeks lowered a sleep difficulty score by 2.9 points more than placebo; its lead author directs the company that sells the product. An earlier 15-day open trial of 600 mg a day of another extract had no placebo group.
Amount studied: 400 mg a day of a phospholipid-bound extract for two to three weeks
In a 96-week trial in older adults with memory concerns, the extract did not change memory and thinking scores compared with placebo.7
The single-dose studies also show why dose matters. The same group found calm rising at one dose, alertness falling at another, and memory tasks slowing at others, depending on the product.1,2
How much people take
Mood and attention studies gave single doses of 300 to 1,600 mg, depending on the product.1,2,11,12
The two placebo-controlled sleep trials used 400 mg a day of a phospholipid-bound extract, either as 200 mg twice a day or as 400 mg in the evening.3,4
There is no official recommended amount, and we found no trial of lemon balm tea on its own. The dosage guide lists every amount studied, from single doses to a 96-week course.
Leaf, tea and extracts
Lemon balm products are made from the leaves. Different preparations of the same plant can act differently: in one study, a dried leaf product had effects that an earlier extract did not.2,8
Both placebo-controlled sleep trials used one branded extract bound to phospholipids, made for better absorption. Results from it may not apply to other lemon balm products.3,4
Our Sleep formula's label says its lemon balm extract comes from the stem, leaves and flower. The studies above used leaf preparations.2,8
What's in ours
What’s in ours
- Sleep: Lemon Balm Extract, 100 mg per serving, from the label
Our Sleep formula contains 100 mg of lemon balm extract per serving. The sleep trials used 400 mg a day of a different, phospholipid-bound extract, so we make no lemon balm claim for it.3,4
Side effects and who should ask first
Lemon balm is generally well tolerated. Nausea, vomiting, stomach pain, dizziness and wheezing have been reported occasionally.5
In single-dose studies, the highest dose of one extract lowered alertness for several hours, and some doses slowed timed memory tasks.1,2
In a three-week trial, mild stomach upset was about as common with lemon balm (4 of 52 people) as with placebo (5 of 48).3
No upper limit has been set for lemon balm. Studies have used single doses of up to 1,600 mg, and an extract providing 500 mg of rosmarinic acid a day for 96 weeks.2,7
In test tube studies, freeze-dried lemon balm extract blocked thyroid stimulating hormone (TSH) from binding to human thyroid cell membranes. We found no study testing whether this happens in people taking a supplement.13
No official source we could find names a specific medicine that interacts with lemon balm. That is not proof of safety. Because some doses lowered alertness, ask before combining it with sedatives or sleep medicines, and ask first if you have a thyroid condition.1,13
- Ask first if you are pregnant or breastfeeding. Nothing is known about lemon balm passing into breast milk5
- Ask first if you take thyroid medicine, sedatives, sleep medicines or any prescription medicine
- Ask first before giving it to anyone under 18
- Do not drive or use machinery if it makes you drowsy1
Questions people ask
Does lemon balm tea work like the extracts in studies?
Not necessarily. The trials used capsules of specific extracts or dried leaf, and different preparations of the same plant can act differently. We found no trial of plain lemon balm tea.2,3
Is lemon balm safe to take every day?
Daily use has been studied for up to 96 weeks in older adults taking an extract providing 500 mg of rosmarinic acid, with no differences from placebo in vital signs or physical measures. It is generally well tolerated, but ask first if you are pregnant, breastfeeding, or take thyroid medicine or sedatives.5,7
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Sources
- Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002;72(4):953-964. Opened 2026-10-07.
- Kennedy DO, Wake G, Savelev S, et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003;28(10):1871-1881. Opened 2026-10-07.
- Bano A, Hepsomali P, Rabbani F, et al. The possible calming effect of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial. Front Pharmacol. 2023;14:1250560. Opened 2026-10-07.
- Di Pierro F, Sisti D, Rocchi M, et al. Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study. Nutrients. 2024;16(23):4199. Opened 2026-10-07.
- Lemon Balm. In: Drugs and Lactation Database (LactMed). Bethesda (MD): National Institute of Child Health and Human Development; 2006 onward. Updated March 15, 2026. Read through PubMed. Opened 2026-10-07.
- Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. PLoS One. 2015;10(5):e0126422. Opened 2026-10-07.
- Noguchi-Shinohara M, Hamaguchi T, Sakai K, et al. Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. J Alzheimers Dis. 2023;91(2):805-814. Opened 2026-10-07.
- Lemon Balm. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012 onward. Updated February 10, 2024. Summary read through PubMed. Opened 2026-10-07.
- Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011;4(3):211-218. Opened 2026-10-07.
- National Center for Complementary and Integrative Health. Herbs at a Glance. Bethesda (MD): National Institutes of Health. Opened 2026-10-07.
- Mathews I, Eastwood J, Bell L, et al. The acute effects of Zensera (Melissa officinalis L.) extract on mood and cognitive performance during cognitive overload: a randomised placebo-controlled, double-blind study in healthy young adults with moderate subjective stress. Ther Adv Psychopharmacol. 2026;16:20451253261415706. Opened 2026-10-07.
- Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (lemon balm). Psychosom Med. 2004;66(4):607-613. Opened 2026-10-07.
- Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984;115(2):527-534. Opened 2026-10-07.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
This page is information, not medical advice. Talk to your doctor or pharmacist about your own situation.