Can You Take Resveratrol With Magnesium?

Quick answer

No official source we read names an interaction between resveratrol and magnesium, and we found no trial of the two together. They raise different questions: magnesium binds some medicines in the gut, while resveratrol at 1 g a day slowed liver enzymes that clear many medicines. Magnesium from supplements is limited to 350 mg a day.^1,2,3,4

Key facts

At 1 g a day for 4 weeks, resveratrol slowed three liver enzymes that clear many medicines and sped up a fourth in 42 healthy volunteers.³
Magnesium can bind tetracycline and quinolone antibiotics and bisphosphonates in the gut, so less of the medicine is absorbed.^2,4
The European Union caps synthetic trans-resveratrol in supplements at 150 mg a day for adults.⁵
In a 29-day study, 0.5 and 1 g of resveratrol a day were tolerated, while 2.5 and 5 g a day caused mild to moderate gut complaints.⁶

What is known about the two together

Nothing documents a problem with the pair, and nothing shows a reason to take them as one. LiverTox lists possible resveratrol interactions with blood thinners and estrogens only, NIH's magnesium fact sheets never mention resveratrol, and a PubMed search found no trial that gave people both.^1,2

They are different kinds of substance. Magnesium is a mineral nutrient with a recommended daily amount. Resveratrol is a plant compound found in grape skins, red wine and peanuts, sold as extracts of Japanese knotweed root, and the body changes most of it into other forms soon after it is absorbed.^4,7,8,9

What each one has been studied for

Magnesium glycinate's one form-specific trial looked at sleep, and resveratrol's best-supported finding is on blood vessel function. Both are graded early below, and neither trial involved the other ingredient.^10,11

May modestly improve self-rated sleep in adults who sleep poorly*^10,12

Early evidence

One randomized, placebo-controlled trial tested this form: 155 adults who slept poorly took magnesium bisglycinate (250 mg of magnesium a day) or placebo for four weeks. Scores on a sleep-problem questionnaire fell a little more with magnesium (3.9 points against 2.3), a small effect, and other measures did not differ. It is a single short trial that relied on self-report. Older trials used other forms at higher doses in older adults and were rated low quality.

Amount studied: 250 mg a day as bisglycinate, 30 to 60 minutes before bed, for four weeks

May support normal blood vessel function*^11,13

Early evidence

A 2022 meta-analysis of randomized trials found a small improvement in flow-mediated dilation, a test of how well an artery widens (about 1.4 percentage points); a 2026 umbrella review rated this as moderate-certainty evidence from 8 trials (603 people) that used 30 to 500 mg a day for 1 to 24 weeks. The trials enrolled mixed groups that included people under medical care, none used this product's 600 mg label dose, and the umbrella review saw weaker or less favorable results overall at 500 mg a day or more.

Amount studied: 30 to 500 mg a day for 1 to 24 weeks

NIH's LiverTox database says there is no conclusive evidence that resveratrol benefits humans.¹

Timing in the studies

In a study of 40 healthy adults taking doses through the day, more resveratrol reached the blood after morning doses than after later ones.¹⁴

Taken after a high-fat meal, a 400 mg dose peaked after a median of 2 hours instead of 30 minutes, but the total amount absorbed did not change in a relevant way.¹⁵

The one trial of magnesium bisglycinate for sleep gave it 30 to 60 minutes before bed. No study tested the two on the same schedule, so the sources neither call for taking them apart nor show any gain from taking them at once.¹⁰

Amounts and limits

Limits and studied amounts for adults^4,5,11,16
	Magnesium	Resveratrol
Upper limit	350 mg a day from supplements and medicines (US)	150 mg a day of synthetic trans-resveratrol in supplements (EU)
Amounts in trials	197 to 994 mg a day	30 to 500 mg a day in the blood vessel trials
Our product, at the label's daily amount	Magnesium Glycinate, 275 mg	Resveratrol, 600 mg of trans-resveratrol from two capsules

Our Resveratrol label directs two capsules a day, 600 mg of trans-resveratrol. That is four times the EU cap and above the amounts in the blood vessel trials, where results were weaker at 500 mg a day or more. Our Magnesium Glycinate stays under the 350 mg limit on its own.^4,5,11

What's in ours

What’s in ours

Magnesium Glycinate: Magnesium, 275 mg per serving, from the label
Men's Multi: Magnesium, 50 mg per serving, from the label
Creatine + Electrolytes: Magnesium, 60 mg per serving, from the label

How each one touches medicines

At 1 g a day for 4 weeks, resveratrol slowed three liver enzymes that clear many medicines (CYP3A4, CYP2D6 and CYP2C9) and sped up a fourth (CYP1A2) in 42 healthy volunteers.³

The European Union requires labels of supplements with trans-resveratrol to say that people taking medicines should use them only under medical supervision, because it may interact with specific medicines.⁵

Ask your pharmacist or doctor first

NIH's LiverTox database lists a possible interaction between resveratrol and anticoagulant blood thinners. The warfarin label asks for more frequent INR checks whenever a botanical product is started or stopped, and MedlinePlus says some supplements may raise the risk of bleeding with warfarin.^1,17,18

Expected from how the two work, not shown in studies

Ask your pharmacist how far apart to take them

Supplements and medicines rich in magnesium can reduce the absorption of oral bisphosphonates such as alendronate. The alendronate label says calcium, antacids and oral medicines containing minerals such as magnesium interfere with its absorption.^2,4,19

On the medicine's label

So the two act on medicines in different places: magnesium in the gut, where it binds some medicines, and resveratrol in the liver, where a high dose changed the enzymes that clear them. If you take a prescription medicine, these are two separate questions for your pharmacist.^2,3

Side effects and who should ask first

Diarrhea and other gut symptoms at 2.5 g a day or more; at 2,000 mg twice a day, 6 of 8 healthy adults had diarrhea.^6,20

In the four-week trial of 250 mg of magnesium a day as bisglycinate, side effects were no more common than with placebo, and 93% of participants reported none.¹⁰

LiverTox lists few side effects: minor stomach upset, nausea, headache and fatigue.¹

One study without a placebo group saw diarrhea in 30% of women past menopause taking 1 g of resveratrol a day, and six of the 40 stopped early because of side effects.²¹

Ask your doctor or pharmacist first if you take any prescription medicine⁵
Ask first if you take a blood thinner or have a bleeding disorder¹
Ask first if you take estrogen or have a hormone-sensitive condition¹
Ask first if you have kidney disease, because the kidneys clear excess magnesium, or liver disease²
Ask first if you are pregnant or nursing, or under 18

Questions people ask

Can you take resveratrol and magnesium at the same time?

No source we read says to keep them apart, and none tested them together. In separate studies, more resveratrol reached the blood after morning doses, and the one sleep trial of magnesium bisglycinate gave it before bed.^10,14

Does magnesium change how resveratrol is absorbed?

No study we found measured it. What is known to shift resveratrol levels is food: a high-fat meal delayed the peak of a 400 mg dose, and at 2,000 mg twice a day a high-fat breakfast cut blood levels by about 45%.^15,20

See what we make

Every product shows its whole label and what its lab report covers. The store opens soon.

See the Full Measure line Creatine + Electrolytes Magnesium Glycinate Men's Multi

Sources

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This page is information, not medical advice. Talk to your doctor or pharmacist about your own situation.