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Healthy Aging

NMN

β-Nicotinamide Mononucleotide 500 mg30 capsules · 30 servings

500 mg beta-nicotinamide mononucleotide
One capsule a day
Vegetable capsule

Coming soon

This product is not on sale yet.

One container is 30 servings: about 30 days at the label amount.

The manufacturer's report for this product lists limits but no measured results. What that means

The whole label

What’s in it

Supplement Facts
Amount per serving	Amount	% Daily Value
Serving size 1 capsule
Servings per container 30
β-Nicotinamide Mononucleotide	500 mg	**
**Daily Value (DV) not established.

Other Ingredients:: HPMC (vegetable capsule), Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate.

Form: Capsule
Contents: 30 capsules
Servings: 30 (1 capsule each)
Lasts: About 30 days at the label amount
Manufactured in: Not stated by the manufacturer
Manufacturer states: gluten-free, vegan friendly, vegetarian

About the ingredients: NMN

Directions

How to take it

Take one capsule a day with water.

Directions on the label

As a dietary supplement, adults take one (1) capsule daily. For best results, take with 6-8 oz (177-237ml) of water or as directed by healthcare professional.

Label warnings

Do not exceed recommended dose. Consult a physician if pregnant, nursing, under 18, or have a medical condition.

Graded honestly

What the evidence says

NMN (beta-nicotinamide mononucleotide) is a compound related to vitamin B3 that the body turns into NAD+, a molecule every cell needs to release energy from food. Human trials show that NMN capsules raise NAD+ levels in the blood. Trials have not shown reliable gains in strength, endurance, blood sugar or other health measures, so this page makes no such claims.

How it works

NAD+ is a helper molecule that enzymes use in energy metabolism. NMN sits one step before NAD+ in the body's own production line, so taking NMN gives cells more raw material to make it. In one trial, blood NAD+ was higher after 30 days and rose more at 600 mg than at 300 mg a day. Whether a higher blood level changes how people feel or function has not been shown, and in one trial NAD+ inside muscle did not change.

The dose in this product

The label dose is one 500 mg capsule a day. Trials that measured blood NAD+ used 250 to 900 mg a day for up to 12 weeks, so 500 mg sits inside the tested range.

How that compares with the studies

Evidence for anything beyond blood NAD+ is weak. The trial closest to this dose (300, 600 or 900 mg for 60 days in adults aged 40 to 65, paid for by the NMN maker) reported longer six-minute walking distance than placebo, but that has not been repeated and its insulin-resistance measure did not improve. In adults over 60, a 2025 meta-analysis found no effect on grip strength, walking speed or muscle mass; nearly all of those trials used 250 mg.

In a 10-week trial of 250 mg in 25 postmenopausal women with above-normal blood sugar, muscle responded better to insulin, but body weight, body fat, blood pressure, blood sugar, blood fats, muscle strength and muscle NAD+ did not change. In 36 healthy adults aged 40 to 59, 250 mg a day for 12 weeks did not significantly change artery stiffness or blood pressure. In 48 amateur runners, six weeks of training plus 600 or 1,200 mg a day improved breathing-threshold measures compared with placebo, while maximal oxygen uptake and peak power did not change.

For these reasons no energy, endurance, strength, metabolism or healthy-aging claim is made.

Moderate evidence
Raises NAD+ levels in the blood
A meta-analysis of 12 randomized trials (513 adults) found that NMN raised blood NAD+, and a 60-day trial in 80 healthy adults aged 40 to 65 found increases at 300, 600 and 900 mg a day. The trials were small and short, several were funded by NMN makers, all carried some risk of bias, and the same meta-analysis found that most health outcomes were no different from placebo. [1][2][7]

Strong evidence: many human trials agree, at the amount in this product. Moderate evidence: human trials mostly agree, but they are small, short or mixed. Early evidence: a few small human studies or lab work. Promising, not proven.

Safety

Who it is for, and who should ask first

Good fit if

Adults who want to raise their blood NAD+ level and accept that health benefits have not been shown
Adults who are not pregnant or nursing
Adults who take no prescription medicines, or whose doctor has agreed to it

Ask your doctor first if

You are pregnant or nursing (safety reviews of NMN exclude pregnant and nursing women)
You are under 18
You take prescription medicines, including medicines for blood sugar
You have a medical condition
You already take niacin, nicotinamide or nicotinamide riboside

Interactions

No drug-interaction studies of NMN in people were found in a PubMed search (October 2026), so interactions are unknown rather than ruled out
Other vitamin B3 supplements (niacin, nicotinamide, nicotinamide riboside): European regulators count NMN as a source of nicotinamide, so these add to the same total
Medicines for blood sugar: one small trial found that NMN changed how muscle responds to insulin, so tell your doctor

Possible side effects

A 60-day trial at 300, 600 and 900 mg a day reported no side effects linked to NMN
A 2026 European safety review of published trials (250 to 1,250 mg a day for 4 to 24 weeks) found no treatment-related serious adverse events
Taking NMN for longer than 24 weeks has not been studied in trials, so long-term effects are unknown

Upper limit

No upper limit has been set for NMN in the United States. In 2026 the European Food Safety Authority judged NMN safe at up to 300 mg a day for adults who are not pregnant or nursing; this product provides 500 mg, which is above the amount that review covered. The human trials EFSA reviewed tested up to 900 mg a day for 60 days and 250 mg a day for 24 weeks without safety problems.

EFSA counts NMN as a source of nicotinamide (a form of vitamin B3), for which Europe's upper level is 900 mg a day; 500 mg of NMN corresponds to about 183 mg of nicotinamide (EFSA Journal 2026;24(5):e10007).

Combining with our other products

Men's Multi supplies 30 mg of niacin, which is close to the 35 mg U.S. upper limit for niacin from supplements (NIH Office of Dietary Supplements niacin fact sheet). NMN is not labeled as niacin in the United States, but European regulators treat it as a source of nicotinamide, another form of vitamin B3, so taking both raises total B3 intake. Resveratrol is often sold alongside NMN; a PubMed search found no randomized human trial of the two together, so there is no evidence the pair works better than either alone.

Apart from the niacin in Men's Multi, no other product in this line lists NMN or a related NAD+ precursor.

Lab reports

What the lab report covers

We hold the manufacturer’s lab report for a production lot of this product. It reports on the manufacturer’s own lot, not on the container you receive. This is what it covers and what it leaves out.

The report lists the formula and its limits, with no measured results.

See every product’s lab report

Strength of the main ingredient: Not measured
Identity test: Not reported
Heavy metals: Limits listed, no results
Microbes: Limits listed, no results
Lab named on the report: No
Latest report: April 2026

Answers

Questions people ask

What does NMN do in the body?

NMN is a building block your cells turn into NAD+, a molecule they need to release energy from food. Trials show that taking NMN raises NAD+ in the blood. Whether that changes your health or how you feel has not been shown.

Will I feel more energy?

The trials do not show that reliably. One trial of 80 adults, paid for by an NMN maker, reported longer walking distance and better self-rated health at 300 to 900 mg a day. A 2025 analysis of trials in adults over 60 found no gain in grip strength, walking speed or muscle mass.

Does NMN slow aging?

No human trial shows that. Interest in NMN comes from animal studies. Human trials so far have measured blood markers and short-term function over weeks, not aging or lifespan.

Why 500 mg?

One capsule gives 500 mg, which is inside the 250 to 900 mg range that raised blood NAD+ in trials. In a trial that compared doses, 600 mg raised NAD+ more than 300 mg, and 900 mg added nothing over 600 mg. Europe's food safety agency has assessed NMN only at up to 300 mg a day, so 500 mg goes beyond that review.

Is NMN legal to sell as a supplement in the United States?

FDA's current position, set out in a letter dated September 29, 2025, is that NMN is not excluded from being a dietary supplement. In 2022 FDA had said the opposite, because NMN was being studied as a drug. FDA changed its view after finding that NMN was already sold as a supplement in the United States as early as 2017.

Is it safe to take long term?

Trials lasting up to 24 weeks have not found safety problems, and a 60-day trial at up to 900 mg a day reported no side effects linked to NMN. Nothing longer has been tested, so long-term safety is unknown.

Can I take it with resveratrol or a multivitamin?

A PubMed search found no human trial of NMN taken together with resveratrol, so there is no evidence the pair works better. Men's Multi already supplies 30 mg of niacin, a form of vitamin B3. European regulators count NMN as a B3 source too, so the two add up.

Who should not take it?

NMN has not been assessed for pregnant or nursing women, who were excluded from the European safety review, or for anyone under 18. The label says to consult a physician in those cases or if you have a medical condition. Talk to your doctor first if you take prescription medicines.

Read the studies

Sources

1.Zhang J, Poon ET, Wong SH. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. Crit Rev Food Sci Nutr. 2025;65(22):4382-4400. Open source (opens in a new tab)Across 12 randomized trials (513 adults), NMN raised blood NAD+, but most clinically relevant outcomes (fasting glucose and blood fats) did not differ from control; seven trials had some risk-of-bias concerns and five were at high risk, and the authors warn that NMN's benefits may be exaggerated.
2.Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023;45(1):29-43. Open source (opens in a new tab)In 80 healthy adults aged 40 to 65, 300, 600 or 900 mg a day for 60 days raised blood NAD+ (most at 600 and 900 mg) and six-minute walking distance versus placebo, with no side effects linked to NMN; an insulin-resistance index did not differ from placebo; fully funded by the NMN manufacturer.
3.Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. Open source (opens in a new tab)In 25 postmenopausal women with above-normal blood sugar and excess weight, 250 mg a day for 10 weeks improved muscle response to insulin by about 25 percent, but body composition, blood pressure, blood glucose, insulin, blood fats, muscle strength, muscle mitochondrial function and muscle NAD+ did not change.
4.Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022;8(1):5. Open source (opens in a new tab)In 42 healthy men aged 65 or older, 250 mg a day for 6 to 12 weeks raised whole-blood NAD+ and gave nominal improvements in walking speed and left-hand grip, with no change in muscle mass, body fat, insulin resistance or blood fats; only 20 men completed 12 weeks, and three authors worked for the NMN maker.
5.Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Open source (opens in a new tab)In 48 amateur runners training for six weeks, 600 and 1,200 mg a day improved oxygen use and power at the ventilatory thresholds more than placebo, while maximal oxygen uptake and peak power did not change in any group; no adverse events were reported.
6.Prokopidis K, Moriarty F, Bahat G, McLean J, Church DD, Patel HP. The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. J Cachexia Sarcopenia Muscle. 2025;16(3):e13799. Open source (opens in a new tab)In trials of adults with a mean age over 60, NMN had no significant effect on muscle mass index, handgrip strength, walking speed or chair-stand time; only one trial used more than 250 mg a day.
7.EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D, Bohn T, Cámara M, et al. Safety of beta-nicotinamide mononucleotide (β-NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC. EFSA J. 2026;24(5):e10007. Open source (opens in a new tab)EFSA concluded NMN is safe at up to 300 mg a day for adults, excluding pregnant and lactating women; 300 mg of NMN supplies about 110 mg of nicotinamide; a 90-day rat study showed reproductive organ changes at the top dose; published human trials raised blood NAD+ and showed no adverse effects at up to 900 mg a day for 60 days.
8.Katayoshi T, Uehata S, Nakashima N, Nakajo T, Kitajima N, Kageyama M, Tsuji-Naito K. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial. Sci Rep. 2023;13(1):2786. Open source (opens in a new tab)In 36 healthy adults aged 40 to 59, 250 mg a day for 12 weeks raised serum nicotinamide, a related NAD+ metabolite, and caused no adverse events, but artery stiffness did not differ significantly from placebo (p = 0.097) and blood pressure did not change; run and funded by a supplement company.

Reviewed 2026-10-01. This page is information, not medical advice.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

NMN