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Healthy Aging

NAD+

NAD+ with Quercetin and Resveratrol60 capsules · 30 servings

500 mg NAD+ per serving
250 mg quercetin from Sophora japonica
150 mg Japanese knotweed extract, 98% resveratrol

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One container is 30 servings: about 30 days at the label amount.

Contains resveratrol and quercetin. Ask a doctor first if you take a blood thinner.

The manufacturer's lab report covers heavy metals, but not strength or microbes. What that means

The whole label

What’s in it

Supplement Facts
Amount per serving	Amount	% Daily Value
Serving size 2 capsules
Servings per container 30
NAD+(Nicotinamide Adenine Dinucleotide)	500mg	**
Quercetin Dihydrate Extract(Sophora japonica) (whole flower bud)	250mg	**
Japanese Knotweed Extract(98% resveratrol) (Polygonum cuspidatum) (root)	150mg	**
**Daily Value not established.

Other Ingredients:: HPMC (vegetable capsule), MCC (microcrystalline cellulose), Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate.

Form: Capsule
Contents: 60 capsules
Servings: 30 (2 capsules each)
Lasts: About 30 days at the label amount
Manufactured in: USA, according to the manufacturer. Where the ingredients come from is not stated.
Manufacturer states: gluten-free, vegetarian, vegan friendly

Directions

How to take it

Take two capsules a day with 6 oz of water.

Directions on the label

As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6oz (177ml) of water or as directed by healthcare professional.

Label warnings

Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. KEEP OUT OF THE REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.

Graded honestly

What the evidence says

Each two capsule serving holds 500 mg of NAD+ (nicotinamide adenine dinucleotide), 250 mg of quercetin from Sophora japonica flower buds and 150 mg of Japanese knotweed extract that is 98% resveratrol, about 147 mg. NAD+ is a molecule every cell uses to release energy from food. We found no published human trial showing that plain NAD+ taken by mouth raises NAD+ in the body. Most of the human evidence is for NMN and nicotinamide riboside, which the body turns into NAD+, so this page makes no NAD+ claim. The one claim it makes rests on the resveratrol, and that evidence is early.

How it works

NAD+ helps enzymes turn food into usable energy. It is a large, fragile molecule. In rat studies, enzymes in the gut split NAD+ into smaller pieces, and nicotinamide, a form of vitamin B3, was the main part absorbed. Cells can rebuild NAD+ from nicotinamide, so swallowed NAD+ may act mostly as a B3 source, but that has not been measured in people taking plain NAD+ capsules. Quercetin is a plant pigment found in onions, apples and tea. Resveratrol is a plant compound found in grape skins; in people it is quickly converted by the gut and liver, and the effect this page relies on is on the lining of blood vessels, which helps arteries widen when blood flow increases.

The dose in this product

NAD+: the only randomized trial of NAD+ taken by mouth that we found tested a proprietary formulation, not plain NAD+. In 50 healthy adults aged 45 to 75, five days of that formulation raised NAD+ inside blood cells by 53% compared with placebo, while NAD+ in blood plasma did not change; the trial was run by people with a financial stake in the product.

How that compares with the studies

Its results do not carry over to the plain NAD+ in this capsule. Human trials that raised blood NAD+ used the precursors NMN or nicotinamide riboside instead. Quercetin: supplements are often sold at up to 1,000 mg a day, and most exercise trials of quercetin used about 1,000 mg; this product gives 250 mg, a quarter of that, so no exercise or recovery claim is made.

Resveratrol: about 147 mg a day sits below the 500 mg level at which a 2026 umbrella review saw weaker or less favorable results. In 27 inactive men around age 65, 250 mg a day blunted the fitness gains from 8 weeks of exercise training. For these reasons no energy, healthy aging, cellular repair, memory, immune, training or recovery claim is made.

Early evidence
Resveratrol may support normal blood vessel function
A 2026 umbrella review of 45 meta-analyses of randomized trials rated, with moderate certainty, a small improvement in flow-mediated dilation, a test of how well an artery widens (about 1.4 percentage points). The same review saw weaker or less favorable results at 500 mg a day or more; this product gives about 147 mg. The trials tested resveratrol on its own, often in people under medical care, and none tested this combination of NAD+, quercetin and resveratrol. [3]

Strong evidence: many human trials agree, at the amount in this product. Moderate evidence: human trials mostly agree, but they are small, short or mixed. Early evidence: a few small human studies or lab work. Promising, not proven.

Safety

Who it is for, and who should ask first

Do not use if

You take NMN from this line. Both products aim at the same NAD+ pathway, and taking them together adds to your vitamin B3 intake with no evidence of extra benefit.

Good fit if

Adults who want quercetin and resveratrol in one capsule and accept that the human evidence is early
Adults who understand that plain NAD+ by mouth has not been shown to raise NAD+ in the body
Adults who take no prescription medicines, or whose doctor has agreed to it

Ask your doctor first if

You take a blood thinner (anticoagulant such as warfarin) or an antiplatelet medicine, or you have a bleeding disorder or surgery coming up
You take any prescription medicine, because quercetin and resveratrol can change how the liver clears many medicines
You have kidney disease or reduced kidney function
You take estrogen or tamoxifen, or have a hormone sensitive condition
You are pregnant or nursing; none of the three ingredients has been studied for safety in pregnancy at these amounts
You are under 18
You already take niacin, nicotinamide, nicotinamide riboside, NMN or a multivitamin with niacin

Interactions

Blood thinners such as warfarin: a man on warfarin had a raised INR (a measure of clotting time) after starting quercetin, which returned to normal when he stopped it, according to Memorial Sloan Kettering's herb database
Antiplatelet and anticoagulant medicines: resveratrol slows platelet clumping in laboratory tests and may raise bleeding risk, according to the same database
Medicines cleared by the liver enzymes CYP3A4, CYP2D6 or CYP2C9: 1 g a day of resveratrol slowed these enzymes in healthy volunteers, which could raise drug levels; this product gives about 147 mg
Medicines cleared by CYP1A2: the same study found resveratrol sped this enzyme up, which could lower drug levels
Medicines cleared by CYP3A4 or CYP2C19: quercetin slowed these enzymes in laboratory studies; how much this matters in people is not known
Losartan and tamoxifen: quercetin raised levels of these medicines in animal studies
Other vitamin B3 sources (niacin, nicotinamide, nicotinamide riboside, NMN): NAD+ contains nicotinamide, so these add to the same total

Possible side effects

Quercetin: side effects in human studies were rare and mild, according to a 2018 review by Germany's Federal Institute for Risk Assessment
Resveratrol: minor stomach upset, nausea and headache have been reported; gut symptoms are more common at grams per day, far above this dose
In the five day trial of a different oral NAD+ formulation, one person had mild nausea and side effects were otherwise similar to placebo
Plain NAD+ capsules have not been tested for safety in a published human trial, so their long term effects are unknown

Upper limit

No upper limit has been set for NAD+, quercetin or resveratrol in the United States. NAD+ contains one nicotinamide unit. If the gut splits it fully into nicotinamide, as rat studies suggest, 500 mg of NAD+ would release about 92 mg of nicotinamide (our calculation from molecular weights; no regulator has assessed NAD+ as a niacin source).

The U.S. upper limit for niacin from supplements, including nicotinamide, is 35 mg a day for adults, set to avoid flushing (Linus Pauling Institute, citing the Food and Nutrition Board). Nicotinamide rarely causes flushing, and liver effects have been reported only at 10 g a day or more. Europe's upper level for nicotinamide is 900 mg a day (EFSA Journal 2026;24(5):e10007).

For resveratrol, the EU authorises synthetic trans-resveratrol in supplements at up to 150 mg a day for adults; this product's 147 mg is just under that.

Combining with our other products

Do not take this with NMN from this line. Both aim to raise NAD+, NMN is the one with human trials showing it does, and together they add to vitamin B3 intake: 500 mg of NMN supplies about 183 mg of nicotinamide by EFSA's method, and this product may supply about 92 mg more. Men's Multi adds 30 mg of niacin.

This line no longer sells resveratrol on its own; if you take a resveratrol product from elsewhere, the amounts add up, and the EU cap for supplements is 150 mg a day. Omega-3 at its label dose supplies 600 mg of EPA and DHA a day; if you take a prescription blood thinner, tell your doctor about both. If you train hard, note that one trial found 250 mg of resveratrol a day blunted fitness gains from exercise.

Lab reports

What the lab report covers

We hold the manufacturer’s lab report for a production lot of this product. It reports on the manufacturer’s own lot, not on the container you receive. This is what it covers and what it leaves out.

The report lists the formula and its limits, with no measured results. A separate report measures heavy metals.

See every product’s lab report

Strength of the main ingredient: Not measured
Identity test: Not reported
Heavy metals: Measured
Microbes: Limits listed, no results
Lab named on the report: No
Latest report: March 2026

Answers

Questions people ask

NAD+ or NMN: which should I take?

If your goal is to raise NAD+ in your blood, NMN is the one with evidence. Randomized trials show NMN capsules raise blood NAD+, while we found no published trial showing that plain NAD+ capsules do. Neither has been shown to improve health, energy or aging in people. Do not take both.

Does NAD+ survive digestion?

Probably not intact. In rat studies, gut enzymes split NAD+ apart and nicotinamide, a form of vitamin B3, was the main part absorbed. The one human trial of oral NAD+ we found used a special formulation designed to get around this, so it does not tell us how plain NAD+ capsules behave.

How much of each ingredient is in a serving?

Two capsules give 500 mg of NAD+, 250 mg of quercetin dihydrate extract from Sophora japonica flower buds, and 150 mg of Japanese knotweed root extract that is 98% resveratrol, about 147 mg. The supplier's lab report on file lists these amounts as formula inputs rather than measured results.

Will I feel more energy?

The research does not show that. No trial of plain NAD+ capsules has measured energy or fatigue. Trials of NMN, which reliably raises blood NAD+, have not shown consistent gains in energy, strength or endurance either.

Does it count toward my vitamin B3?

Probably. NAD+ contains nicotinamide, a form of vitamin B3, and gut enzymes release it during digestion. By our calculation 500 mg of NAD+ holds about 92 mg of nicotinamide. That is above the 35 mg U.S. upper limit for niacin from supplements, which was set to avoid flushing, a side effect nicotinamide rarely causes.

Can I take it with a blood thinner?

Ask your doctor first. A man taking warfarin had a raised clotting time reading after starting quercetin that settled when he stopped it, and resveratrol slows platelet clumping in laboratory tests. Both can also change how the liver clears other medicines.

Is it safe for my kidneys?

For most healthy adults at 250 mg a day, quercetin has caused few side effects in human studies. A 2018 safety review by Germany's Federal Institute for Risk Assessment found animal evidence that quercetin may worsen damage in a kidney that is already injured. If you have kidney disease, ask your doctor before taking it.

Can I take it while pregnant or nursing?

Talk to your doctor first. None of the three ingredients has been tested for safety in pregnancy or nursing at these amounts, and the label says pregnant or nursing mothers should consult a physician.

Read the studies

Sources

1.Kornilov SA, Hastings WJ, McGrath LF, et al. Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. Geroscience. 2026 Jul 30. Online ahead of print. Open source (opens in a new tab)In 50 analysed healthy adults aged 45 to 75, five days of a proprietary oral NAD+ formulation raised NAD+ inside whole blood cells by 53% versus placebo, did not change plasma NAD+, and raised NAD+ breakdown products; no secondary health measure survived correction for multiple testing, one mild nausea case occurred, and several authors hold stock in the maker.
2.Gross CJ, Henderson LM. Digestion and absorption of NAD by the small intestine of the rat. J Nutr. 1983;113(2):412-420. Open source (opens in a new tab)In rats, an enzyme in intestinal juice split NAD+ into smaller pieces, and nicotinamide was the main, if not the only, labeled part absorbed.
3.Sun JN, Yang R, Fang L, et al. Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. Nutr J. 2026;25(1):63. Open source (opens in a new tab)Across 45 meta-analyses of randomized trials, resveratrol improved flow-mediated dilation by about 1.4 percentage points with moderate certainty; the authors observed weaker or less favorable effects at 500 mg a day or more and beyond 12 weeks.
4.Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 2013;591(20):5047-5059. Open source (opens in a new tab)In 27 inactive men around age 65 doing 8 weeks of high intensity training, the gain in maximal oxygen uptake was 45 percent greater with placebo than with 250 mg of trans-resveratrol a day.
5.Andres S, Pevny S, Ziegenhagen R, et al. Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res. 2018;62(1). Open source (opens in a new tab)Germany's Federal Institute for Risk Assessment found that side effects of supplemental quercetin in human studies were rare and mild, that supplements often provide up to 1,000 mg a day, that long term safety data are lacking, and that quercetin can alter how some medicines are absorbed and cleared.
6.Linus Pauling Institute Micronutrient Information Center. Niacin. Oregon State University. Open source (opens in a new tab)The U.S. Food and Nutrition Board set the adult upper limit for niacin, covering nicotinic acid and nicotinamide, at 35 mg a day to avoid flushing; nicotinamide rarely causes flushing, and liver effects appear at 10 g a day or more.
7.Memorial Sloan Kettering Cancer Center. About Herbs: Quercetin. Updated October 10, 2023. Open source (opens in a new tab)Lists a case of raised INR in a man on warfarin that resolved after stopping quercetin, slowing of CYP3A4 and CYP2C19 in laboratory studies, and raised tamoxifen and losartan levels in animals.
8.Memorial Sloan Kettering Cancer Center. About Herbs: Resveratrol. Updated February 17, 2023. Open source (opens in a new tab)Says resveratrol may increase bleeding risk with blood thinners and antiplatelet drugs, and that in healthy volunteers it slowed CYP3A4, CYP2D6 and CYP2C9 and sped up CYP1A2.

Reviewed 2026-10-13. This page is information, not medical advice.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.