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Is resveratrol safe during pregnancy?

Written by the Full Measure editorial team, which sells supplements. Approved for publication by the Full Measure owners. Updated .

Drafted with AI assistance from the sources listed below. How we write these

Quick answer

We found no official finding on resveratrol supplements in pregnancy. A 2019 systematic review of 31 animal studies found that maternal and fetal outcomes differed by species and pregnancy model, and the one human pregnancy study we found tested a product that combined resveratrol with inositols. Anyone who is pregnant should ask their doctor first.1,2

Key facts

  • NIH's Office of Dietary Supplements says many supplements have not been well tested for safety in women who are pregnant or nursing, and to be cautious beyond a standard prenatal supplement.3
  • A 2019 systematic review of 31 animal studies in rats, mice, macaques and sheep found that maternal and fetal outcomes differed by species and pregnancy model.1
  • In rats, one high-purity trans-resveratrol product caused no adverse reproductive effects in an embryo-fetal toxicity study at 750 mg per kg of body weight a day.4
  • The only human pregnancy study we found randomized 110 overweight pregnant women to a product that combined trans-resveratrol with inositols, and its abstract does not report side effects.2

What do NIH sources say about resveratrol in pregnancy?

NIH's Office of Dietary Supplements says to be cautious with dietary supplements, beyond a standard prenatal supplement, if you are pregnant or nursing, because many supplements have not been well tested for safety in pregnant women. That is general guidance, not a finding about resveratrol.3

NIH's LiverTox and LactMed databases both have resveratrol records, but the summaries we read do not speak to pregnancy, and NCCIH has no resveratrol page that we could find on October 11, 2026. So no official source we opened gives a finding on resveratrol supplements in pregnancy.5,6

What do animal studies of resveratrol in pregnancy show?

A 2019 systematic review found 31 studies of resveratrol given during pregnancy: 18 in rats, 7 in mice, 3 in Japanese macaques and 3 in sheep. The animals were in different models, such as maternal diet changes, diabetes, low oxygen and exposure to a harmful substance, and the doses and routes differed. Maternal and fetal outcomes varied with the species and the model, so the reviewers said further investigation is warranted and suggested a minimum set of data for future studies.1

A 2009 paper reported safety studies of one high-purity trans-resveratrol product in rats. It found no adverse effects in 28-day and 90-day studies at the doses tested, and no adverse reproductive effects in an embryo-fetal toxicity study at 750 mg per kg of body weight a day. The same paper reported chromosome damage in a human cell test that was not seen in a rat test. Animal results are not a safety finding for pregnant women, and doses per kilogram in rats cannot be compared directly with a capsule.4

Has resveratrol been tested in pregnant women?

We found one randomized pilot study. It assigned 110 overweight pregnant women to a product that combined trans-resveratrol with two inositols, to the inositols alone, or to a control group, for 30 and 60 days. Its abstract reports blood fat and glucose results. It says nothing about side effects or the babies, and because the product mixed ingredients, the effect of resveratrol alone cannot be separated.2

We did not find a trial designed to test the safety of resveratrol in pregnancy when we searched PubMed on October 11, 2026.

What about resveratrol skincare in pregnancy?

People also search for skincare serums and creams that contain resveratrol. None of the sources we opened addresses resveratrol applied to the skin in pregnancy, and the studies above concern resveratrol taken by mouth or given to animals. That is not a finding either way, so ask your doctor, midwife or dermatologist about the ingredient list of any skincare product.

Who should ask a doctor before using resveratrol during pregnancy?

  • Anyone who is pregnant, before using a resveratrol supplement, because NIH says many supplements have not been well tested in pregnancy.3
  • Anyone who takes a prescription medicine, because at 1 g a day for 4 weeks resveratrol slowed three liver enzymes that clear many medicines in healthy adults.7
  • Anyone who takes a blood thinner, because NIH's LiverTox database lists a possible interaction with anticoagulants.5
  • Anyone with liver problems.5

Bring the label of any supplement or skincare product you use, so your doctor can see the ingredients and amounts.3

Questions people ask

Is resveratrol safe for pregnancy?

We found no official finding on resveratrol supplements in pregnancy. NIH's Office of Dietary Supplements says many supplements have not been well tested in pregnant women, so ask your doctor before using one.3

Is topical resveratrol safe during pregnancy?

None of the sources we opened addresses resveratrol applied to the skin in pregnancy, so there is no finding either way. Ask your doctor, midwife or dermatologist about the ingredient list of any skincare product.3

Is trans resveratrol safe during pregnancy?

A 2009 rat study of high-purity trans-resveratrol found no adverse reproductive effects at the dose tested, and a 2019 review found mixed results across animal species. Neither is a study in pregnant women, so ask your doctor.1,4

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Sources

  1. Darby JRT, Mohd Dollah MHB, Regnault TRH, Williams MT, Morrison JL. Systematic review: Impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications. Are we ready for the clinic? Pharmacol Res. 2019;144:264-278. Opened 2026-10-11.
  2. Malvasi A, Kosmas I, Mynbaev OA, et al. Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant patients? Clin Ter. 2017;168(4):e240-e247. A randomized, double-blinded, placebo-controlled pilot study. Opened 2026-10-11.
  3. National Institutes of Health, Office of Dietary Supplements. Dietary Supplements: What You Need To Know. Fact sheet for consumers. Updated January 4, 2023. Opened 2026-10-07.
  4. Williams LD, Burdock GA, Edwards JA, Beck M, Bausch J. Safety studies conducted on high-purity trans-resveratrol in experimental animals. Food Chem Toxicol. 2009;47(9):2170-2182. Opened 2026-10-11.
  5. Resveratrol. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Updated November 30, 2024. Opened 2026-10-01.
  6. Resveratrol. In: Drugs and Lactation Database (LactMed). Bethesda (MD): National Institute of Child Health and Human Development; 2006 onward. Updated September 20, 2021. Chapter summary read through PubMed (PMID 30000939); the Bookshelf page showed a browser check and was not opened. Opened 2026-10-11.
  7. Chow HH, Garland LL, Hsu CH, et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010;3(9):1168-1175. Opened 2026-10-01.

This page is information, not medical advice. Talk to your doctor or pharmacist about your own situation.