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Medicines and supplements

Can you take CoQ10 with blood thinners like warfarin?

Written by the Full Measure editorial team, which sells supplements. Approved for publication by the Full Measure owners. Updated .

Drafted with AI assistance from the sources listed below. How we write these

Quick answer

Ask your pharmacist or doctor before combining. The warfarin label lists coenzyme Q10 among products that may decrease warfarin's effect, and NIH's complementary health center says the two may interact. The label advises more frequent INR checks when such products are started or stopped.1,2

Key facts

  • MedlinePlus lists coenzyme Q10 among the nonprescription products that may interact with warfarin, and says not to start one without talking to your healthcare provider.3
  • An NIH summary says CoQ10 can reduce the body's response to warfarin.4
  • The warfarin label groups CoQ10 with St. John's wort and ginseng as botanicals that may weaken warfarin, unlike garlic and ginkgo, which may add to its effect.1
  • These sources name warfarin only. They do not name apixaban, rivaroxaban or other blood thinners with CoQ10.2,5

Ask your pharmacist or doctor first

CoQ10 may make the blood thinner warfarin less effective. The warfarin label lists coenzyme Q10 among products that may decrease warfarin's effects and advises more frequent INR checks when starting or stopping them. NIH's complementary health center and MedlinePlus also list the interaction.1,2,3,4

On the medicine's label

What is documented

Three official sources list the interaction. NIH's complementary health center says CoQ10 may interact with the anticoagulant warfarin. MedlinePlus names coenzyme Q10 among the products that may interact with warfarin. The warfarin label, in its section on botanical products, says some may decrease warfarin's effects and gives coenzyme Q10 as an example.1,2,3

Warfarin is an anticoagulant, a blood thinner, and its effect is checked with a regular blood test called the INR. A product that weakens warfarin can change that result, which is why the label asks for more frequent checks.1,3

What the warfarin label and MedlinePlus advise

The label advises more frequent INR monitoring when botanicals are started or stopped. It notes that few good studies of botanicals with warfarin exist, and that the active ingredients in such products can vary from one to the next.1

MedlinePlus says your doctor may change the doses of your medicines or monitor you carefully, and asks you not to start any of the products it lists while taking warfarin without discussing it first.3

Other blood thinners

The sources on this page name warfarin only. The MedlinePlus page for apixaban lists St. John's wort, aspirin and NSAIDs among the nonprescription products that may interact, without naming CoQ10, and asks you to tell your doctor and pharmacist about every supplement you take. That is not a finding either way, so ask your pharmacist about your own blood thinner.5

How it is known

  • On the medicine's label: the warfarin label names coenzyme Q10 among botanicals that may decrease its effects.1
  • Listed by NIH and MedlinePlus: both name the interaction without saying how large it is.2,3

What to ask your pharmacist

  • Should my INR be checked more often if I start or stop CoQ10?
  • Does my blood thinner appear in any official source for CoQ10?
  • Do any of my other supplements, such as St. John's wort or ginseng, also affect warfarin?

Tell whoever manages your warfarin before you start or stop CoQ10, and bring the label of every supplement you take.

Questions people ask

Can I take CoQ10 with apixaban?

The sources on this page do not name apixaban with CoQ10, and the MedlinePlus page for apixaban does not list it among products that may interact. That is not a finding either way, so ask your pharmacist or the doctor who prescribed apixaban.5

I already take both. What should I do?

Do not stop or start either one on your own. Tell the person who manages your warfarin, because the label advises more frequent INR checks when products like CoQ10 are started or stopped.1

Does the form of CoQ10 matter?

The sources refer to coenzyme Q10 in general and do not separate ubiquinone from ubiquinol. Ask your pharmacist about the product you take.2,3

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Sources

  1. Warfarin sodium tablets: prescribing information (Amneal Pharmaceuticals). DailyMed, U.S. National Library of Medicine. Published June 3, 2026. Opened 2026-10-07.
  2. National Center for Complementary and Integrative Health (NIH). Coenzyme Q10. Last updated January 2019. Opened 2026-10-07.
  3. MedlinePlus. Warfarin. U.S. National Library of Medicine. Last revised March 15, 2026. Opened 2026-10-07.
  4. PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Coenzyme Q10 (PDQ): Health Professional Version. National Cancer Institute. Updated October 31, 2024. Opened 2026-10-07.
  5. MedlinePlus. Apixaban. U.S. National Library of Medicine. Last revised October 15, 2025. Opened 2026-10-07.

This page is information, not medical advice. Talk to your doctor or pharmacist about your own situation.